Over time, the popularity of cannabidiol (CBD) is increasing as much as it is expanding. It happens because of the amazing health healing properties of CBD. These properties have helped CBD found a strong ground and a new platform of herbal and natural treatments. Another cause of it is its anti-inflammatory properties without any severe side effects.
But you may be curious to know- How does CBD work? How long does CBD take to work? How does CBD oil work? Let us run you through how CBD works in the body and the brain and how CBD interacts with cannabinoid receptors. So go through this article to get all your answers!
What is Cannabidiol (CBD)?
Cannabidiol (CBD) is one of the most well-known natural cannabinoids and the second most prevalent chemical compound in cannabis hemp and marijuana plants. CBD comes from a class of molecules called phytocannabinoids and has a non-psychoactive property. This compound of the plant can keep you healthy without getting you high.
The FDA-approved CBD is generally extracted as an oil from the cannabis hemp plant through several different extraction processes. CBD oil is used in various products such as capsules, tinctures, edibles, gummies, and more. CBD produces effects in the body by binding and interacting with certain cannabinoid receptors in the endocannabinoid system.
How Does CBD Interact With Cannabinoid Receptors?
Cannabinoid receptors are firmly fixed in the cell membranes throughout the human body. They help regulate multiple processes of our daily experiences like mood, appetite, memory and pain sensation. While these cannabinoid receptors are activated, naturally occurring endocannabinoids and phytocannabinoids from hemp and cannabis can cause these processes to happen.
Two major cannabinoid receptors – CB1 and CB2 are prevalent in the human body cell membranes. You should know that THC directly stimulates these two cannabinoid receptors- CB1 and CB2, but CBD works differently. CBD interacts with multiple receptors in the body, including the cannabinoid, dopamine, opioid and serotonin receptors.
Although once scientists believed CBD would attach to the CB2 receptors, some new studies have shown that CBD does not exactly attach to any receptor. Instead, CBD impacts the endocannabinoid system by signaling through CB1 and CB2 receptors indirectly. That is why CBD is non-intoxicating in contrast to THC. In addition, CBD can raise the levels of the body’s natural cannabinoids, the endocannabinoids, by inhibiting the enzymes that break them down.
After taking CBD, the compound goes into the body’s endocannabinoid system (ECS) and creates its therapeutic benefits by indirect action for its not having a particular binding affinity. CBD also restrains fatty acid amide hydrolase (FAAH) from breaking down anandamide and weakening it.
CBD weakens FAAH, leading to an increased concentration of anandamide, which only positively affects the endocannabinoid system. Anandamide is considered the “bliss molecule” as it plays a crucial role in generating pleasure and motivation.
CBD is found to affect the fatty acid-binding protein (FABP), which binds to anandamide and takes the enzyme outside the synapse for FAAH to break down and metabolize it. CBD also negatively impacts the transportation process of FABP for a less metabolization of anandamide and a higher concentration of it.
And finally, CBD makes itself attached to the G-protein receptors, TRPV-1, which helps regulate body temperature, pain, and inflammation. Thus CBD helps with pain relief.
How Does CBD Work in The Human Body?
Let us explain how CBD works in the body for different people as promised. Every person is different for having a different number of receptors in their body. For the same reason, some can be overexpressed or under-expressed. The same receptors can respond to a variety of cannabinoids. This variety complicates the development of therapeutic grades for researchers because everyone responds to the medications differently.
CBD is a cannabinoid, but it doesn’t bind directly with either cannabinoid receptors- CB1 and CB2. Rather, CBD works in the body by slowing down the breakdown of the body’s internal endocannabinoids. Your body can then work more readily to reduce inflammation in the brain and nervous system with greater efficiency by slowing the breakdown.
How Does CBD Work in The Brain?
CBD does not influence the brain the same way that THC does. CBD does not get you high. CBD interacts with a variety of receptor systems in the brain, either directly or indirectly. It decreases THC’s ability to stimulate the receptor and indirectly influences the major cannabinoid receptor in the brain.
The brain has a large number of neurons, the highly specialized cells. Through the synapses, each neuron connects to many others. In these sites, one neuron communicates to another by releasing chemical messengers- neurotransmitters. The sensitivity of a neuron to a specific neurotransmitter depends on whether or not it contains a receptor that “fits” that transmitter just as an electrical socket fits a plug.
If a neuron has receptors matching a particular neurotransmitter, it can respond directly to that transmitter. Otherwise, it generally cannot respond. All the neurons contain multiple neurotransmitter receptors. Those receptors allow them to respond to some specific neurotransmitters but not others. Brain receptors are sensitive to the naturally produced neurotransmitters, like dopamine or serotonin, and some chemical messengers produced outside the body, like plant cannabinoids- THC or CBD.
So by ingesting an edible or inhaling some vapor, you’re allowing the plant-produced compound CBD to enter your body, then travel through your bloodstream, and finally enter your brain. When it enters the brain, this plant-derived CBD can influence brain activity by interacting with the receptors on neurons. But there, it doesn’t interact with all neurons. But just those having the appropriate receptors.
How Long Does It Take for CBD Oil to Work?
Before understanding how long it takes for CBD oil to work, you must know how different variables can impact its onset of action. Usually, CBD can enter the bloodstream within 20 minutes to 2 hours, depending on the delivery method.
Other variables such as the dosage, consistency, full-spectrum or THC-free, and quality, also play a vital role in how quickly CBD provides you benefits. So, CBD’s real benefits depend on your age, body weight, metabolism, besides your goals and expectations.
However, make consistency and patience a part of your wellness routine to attain the full potential of CBD.
The Bottom Line
CBD has multiple benefits, but there is still a lot to study regarding the endocannabinoid system and CBD’s role. But it’s undeniable that CBD delivers a positive effect on the endocannabinoid system and treats many different medical conditions.