Entourage effect formula of cbd

The Entourage Effect – How Cannabis Compounds May Work Together

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There are more than 100 different phytocannabinoids in cannabis plants. After being ingested, these phytocannabinoids take part in acting on your endocannabinoid system, which performs to keep your body’s homeostasis or simply the right balance for your body. Besides THC and CBD, the plant produces many other compounds in lesser abundance that play a supporting role in the holistic effects of a particular strain.

Those different cannabis compounds work together to create a unique effect, and this synergistic effect is called the entourage effect or the cannabis entourage effect. But many people don’t know the actual CBD entourage effect and its benefits. This article aims at clarifying and refining your ideas about this entourage effect.

What is the Entourage Effect?

When we smoke or vape cannabis, our bodies take in many different natural chemical compounds, each of which arrives with unique effects and benefits. During this time, their behavior may change in the presence of other compounds that work synergistically to boost their effect, which is the entourage effect. The term “Entourage Effect” describes the enhanced effects of natural cannabinoids, including CBD – when numerous compounds synergistically work together rather than alone.

Although that synergistic effect is known as the Entourage Effect, cannabis is far more than just THC and CBD. It also produces many other cannabinoids such as CBN, CBC, CBG, and more with terpenes. For such a diversity of beneficial compounds in cannabis, the created synergies may make your head spin with excitement.

cannabis leaves

What Research Shows

Several conditions have been studied with the entourage effect. Research on the entourage effect shows the following vital points: Phytocannabinoids and Terpenes Getting Together Can Provide Some Additional Therapeutic Benefits. In 2001, two highly notable and famous researchers John McPartland and Ethan Russo published a paper, “Cannabis and Cannabis Extract: Greater Than the Some of Their Parts.”

One review of studies in 2001 in the British Journal of Pharmacology identified that ingesting terpenes and phytocannabinoids together may be beneficial for alleviating:

  • Pain
  • Inflammation
  • Anxiety
  • Epilepsy
  • Cancer
  • Fungal infection

CBD May Help in Reducing Unwanted Effects of THC

After taking THC, some people have been found to experience unexpected side effects like anxiety, hunger, and sedation. The 2011 review suggests that CBD may help reduce these side effects. Phytochemicals- Terpenes and Flavonoids Can Be Beneficial to Brain Health.

Research from 2018 shows that certain flavonoids and terpenes may create neuroprotective and anti-inflammatory effects to improve CBD’s therapeutic potential. Like medical cannabis, the entourage effect is a well-supported theory right now, although not all research has found evidence to support it.

By testing six common terpenes both alone and in combination, the researchers of a 2019 study discovered that the effects of THC on the cannabinoid receptors CB1 and CB2 did not change after the addition of terpenes. But this doesn’t mean that the entourage effect doesn’t exist at all. Rather it means that more research is required.

Cannabinoids and Terpenes Potentially Work Together

Everyone knows about CBD or THC. But you should know that hemp contains much more than just those two cannabinoids. Research believes that the entourage effect emerges from the interactions between cannabinoids and between terpenes and cannabinoids. And this theory of the entourage effect is widely described in a review, which is called “Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects,”

Cannabinoids and terpenes: THC (diamonds), pinene (green), myrcene (blue), caryophyllene (fuchsia)
Potential synergies: After understanding the potential benefits of THC, myrcene, and caryophyllene, one can recommend this strain to someone looking to achieve sleep while simultaneously addressing pain and inflammation.

Some more potential synergies in “Taming THC” include:

  • The pine-scented terpene pinene may be helpful to counteract the compromised memory that THC causes.
  • In the treatment of addiction, a combination of CBD and peppery terpene caryophyllene may be beneficial.
  • CBD and the citrus-scented terpene limonene can work together to remove anxiety.
  • THC and the cannabinoid CBN can potentially yield enhanced sedating effects.

THC and CBD Only Medicines

Since cannabis flower is a raw herbal product, it contains a wide variety of cannabinoids and terpenes without any doubt. Besides, some cannabis extracts are also found to offer a rich diversity of cannabinoids and terpenes, and so, we call these extracts the full-spectrum cannabis extracts.

Among THC-only medicines, the synthetic renderings of THC are mentionable, which are the two most common FDA-approved pharmaceuticals- Marinol (dronabinol) and Cesamet (nabilone). These are often prescribed for the treatment of cancer-related nausea or pain. But in the 2010 study, these isolate medicines may not be as effective as combination medicines containing both THC and CBD.

Considering CBD’s help in curbing the adverse side effects of THC, notably anxiety, it’s easy to imagine why some people prefer a combination over pure THC. A 2011 survey based on consumption found that only 1.8% of 953 patients preferred synthetic THC isolates over inhaled or infused methods.

Final Thoughts

While CBD and THC have the top of the talk among some people for their multiple medicinal benefits and uses, such innovative combinations between terpenes and cannabinoids have not been considered earlier in existing scientific research.

But still, the entourage effect is a theory. More research and studies into the cannabis plant and its chemical compounds are essential for learning the full scale of its potential medical benefits.

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